​A research team led by Assistant Professor Yang Bei at the School of Life Science and Technology (SLST) and Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and Professor Chen Jia at SLST, ShanghaiTech University, has achieved a significantprogress in mitochondrial DNA (mtDNA) editing. Their study, published in Molecular Cell, revealed the first structural snapshots of functioning DdCBE, a mitochondrial base editor.

​On July 7, a research team led by Research Associate Professor Zhang Heqiao and Distinguished Adjunct Professor Roger Kornberg (Lab of Structural Biochemistry) at Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, published a research article in Cell. The study, titled “Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition,” elucidates the molecular mechanism by which non-nucleoside inhibitors suppress

On December 11, the Laboratory of Structural Biochemistry at Shanghai Institute for Advanced Immunochemical Studies (SIAIS), led by Distinguished Adjunct Professor Roger Kornberg and Research Associate Professor Zhang Heqiao, published a research article in Science Advances titled “Cryo-EM Structure of Nipah Virus RNA Polymerase Complex.” This study provides a detailed characterization of the structural features of the Nipah virus polymerase complex.

​Recently, the Laboratory of Structural Biochemistry at SIAIS, led by Distinguished Adjunct Professor Roger Kornberg and Research Associate Professor Zhang Heqiao, published a research article entitled “Class I histone deacetylase complex: structure and functional correlates” in the Proceedings of the National Academy of the Sciences (PNAS), reporting a 3.2 Å resolution cryo-EM structure of the class I histone deacetylase (HDAC) complex.