We welcome you to visit and use our research group’s new homepage and services! https://bailab-shanghaitech.siais.shanghaitech.edu.cn/

       Research in the Bai Group aims to create an efficient drug design framework by combining state-of-the-art computational drug design methods with chemical biology technologies. We are particularly interested in developing new computational biology and drug design methods by introducing artificial intelligence algorithms, such as protein-protein interaction prediction, peptide design, molecular degrader design, and selective covalent inhibitor design, etc. Using these methods, we explore the molecular mechanisms involved in the development of serious diseases, such as cancer, infectious diseases, and metabolic diseases, and develop therapeutic agents accordingly.

       To date, we have developed a number of computational drug design programs, most of which are freely available on our website for academic use. Using these methods, we have successfully designed several highly bioactive compounds or peptides. Some of them are being studied in detail in preclinical phases. The corresponding work has been published or filed as patents.

         The Bai lab is supported by the National Natural Science Foundation of China, the Ministry of Science and Technology, the Shanghai Science and Technology Commission, the Shanghai Science and Technology Development Funds, and the Start-up Package of Shanghaitech.